4/16/21: PAPER
“ZNF410 represses fetal globin by singular control of CHD4” is out in Nature Genetics. Congrats Divya!
2/3/21: PAPER
Our collaborative work with Pinello lab “Motif-Raptor: A Cell Type-Specific and Transcription Factor Centric Approach for Post-GWAS Prioritization of Causal Regulators” is out in Bioinformatics. Congrats Qiuming!
2/3/21: NEWS
Dan appointed Director of Gene Therapy Program and Dagres Family Chair in Gene Therapy, Boston Children’s Hospital.
1/28/21: PAPER
“Dissecting ELANE neutropenia pathogenicity by human HSC gene editing” is out in Cell Stem Cell. Congrats Shuquan and Yao!
9/8/20: PAPER
Our collaborative work with Tisdale lab “BCL11A enhancer-edited hematopoietic stem cells persist in rhesus monkeys without toxicity” is out in JCI. Congrats Selami and Jing!
7/2/20: NEWS
Dan promoted to Associate Professor at Harvard Medical School.
5/4/20: AWARD
Dan receives the ASGCT Outstanding New Investigator Award.
3/17/20: PUBLICATION
Therapeutic base editing of human hematopoietic stem cells is out in Nature Medicine. Congrats Jing, Yuxuan and Chunyan!
12/8/19: PRESENTATION
Shuquan presents a Plenary Abstract at the ASH Annual Meeting “Gene Editing ELANE in Human Hematopoietic Stem and Progenitor Cells Reveals Disease Mechanisms and Therapeutic Strategies for Severe Congenital Neutropenia.”
11/21/19: EVENT
Excited to share science and cheers at the Science in the News event “Science by the Pint” at Aeronaut Brewery Company in Somerville.
9/13/19: AWARD
Steve’s F31 is official. Congrats Steve and thanks NIDDK/NIH!
6/28/19: PUBLICATION
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis is out in Nature Genetics. Congrats Falak and Mir!
4/2/19: BLOG
We are honored that Yuxuan and Jing’s BCL11A enhancer editing work was profiled by Dr. Collins in the NIH Director’s Blog.
3/25/19: PUBLICATION
Highly efficient therapeutic gene editing of human hematopoietic stem cells is out in Nature Medicine. Congrats Yuxuan and Jing!
3/6/19: PUBLICATION
CRISPResso2 provides accurate and rapid genome editing sequence analysis is out in Nature Biotechnology. Congrats Kendell! Fantastic collaboration with Luca Pinello lab. Tool is here and here.
1/31/19: PUBLICATION
Editing aberrant splice sites efficiently restores β-globin expression in β-thalassemia is out in Blood. Congrats Shuqian! Fantastic collaboration with Scot Wolfe lab.
1/18/19: FAREWELL
Shuqian Xu returns as a staff hematologist to Qilu Hospital, Shandong University, Jinan, China.
1/9/19: WELCOME
Pim Rullens, master’s student in medical epigenomics from Radboud University, joins the lab.
1/2/19: WELCOME
Jasmine Bonanno, research assistant, joins the lab.
11/13/18: WELCOME
Mike Peters, postdoctoral fellow, joins the lab.
10/24/18: PUBLICATION
CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis is out in Genome Biology. Congrats Mitchel and Vivien! Great collaboration with Luca Pinello lab.
9/1/18: WELCOME
Anne Shen, research assistant, joins the lab.
8/15/18: PREPRINT
CRISPResso2. Analysis of genome editing (Cas9, Cas12a, base editor) outcomes from deep sequencing data. Led by Kendell Clement in Luca Pinello’s lab. Webtool (command line available too) and bioRxiv.
8/1/18: FAREWELL
Yuxuan Wu begins his faculty position at East China Normal University, Shanghai. Mitchel Cole begins his MD-PhD studies at UCSF.
7/1/18: WELCOME
Sabine Studer, postdoctoral fellow, and Devlin Shea, research assistant, join the lab.
6/13/18: PREPRINT
CRISPR-SURF. Design, visualize, analyze CRISPR tiling data. Identify functional noncoding elements. Webtool (command line available too). Led by Jonathan Hsu in Luca Pinello’s lab. Posted on bioRxiv.
6/4/18: WELCOME
Summer students Jacob Ukleja (Duke), Rachel Kim (Wellesley), Anna Victoria Serbin (Harvard), Nathanaelle Onyi Ibeziako (Tufts Med, ASH MMSAP awardee) arrive.
5/30/18: CONGRATS!
Steve aces his HMS BBS Ph.D. Qualifying Exam.
5/23/18: CONGRATS!
Yuxuan wins abstract award at Boston Children’s Hospital Folkman Research Day.
5/19/18: PREPRINT
Our manuscript “CRISPRO Identifies Functional Protein Coding Sequences Based on Genome Editing Dense Mutagenesis” is on bioRxiv. Find the tool here. Congrats Vivien and Mitchel. Terrific collaboration with Pinello lab.
3/1/18: WELCOME
Chunyan Ren, new postdoctoral fellow, joins the lab, after her PhD at Mount Sinai School of Medicine.
2/1/18: WELCOME
Shuquan Rao, new postdoctoral fellow, joins the lab, after his PhD at Peking Union Medical College and postdoctoral fellowship at St. Jude Children’s Research Hospital.
1/16/18: WELCOME
Joseph Crooks (Northeastern University) and Saher Siddiqui (Harvard College) join as undergraduate student researchers.
1/10/18: PRESENTATION
Dan presents as student invited speaker at the Genetics Institute, University of Florida, Gainesville, Florida.
12/10/17: PRESENTATION
Falak Sher presents oral abstract at American Society of Hematology annual meeting, “High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control.”
11/1/17: WELCOME
Steve Coyne, Harvard BBS student, joins the lab.
10/17/17: WELCOME
Shuqian Xu, visiting hematologist from Shandong University (China), joins the lab.
10/1/17: FAREWELL
Falak Sher, starts his faculty position as a member of the Taub Institute at Columbia University.
9/18/17: WELCOME
Qiuming Yao, new postdoctoral fellow, joins the lab.
8/21/17: WELCOME
Steve Coyne, Harvard BBS student, starts his lab rotation.
7/17/17: PUBLICATION
Our paper “An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility” is out in JCI. Congrats to Emily! Thanks Sam and Guillaume for the terrific collaboration!
6/7/17: PRESENTATION
Dan delivers oral presentation Genome Editing for Sickle Cell Disease at a Congressional Briefing On Sickle Cell Disease & Gene Editing, hosted by The House Research & Development Caucus, The Congressional Caucus to Cure Blood Cancers and Other Blood Disorders, and The Congressional Sickle Cell Disease Caucus.
6/5/17: WELCOME
Ana Quinones Ramos, medical student from University of Puerto Rico School of Medicine, starts as a summer student.
5/15/17: WELCOME
Mir Hossain, new postdoctoral fellow, recently graduated from the University of Florida, joins our lab.
5/8/17: PRESENTATION
Dan presents at the Pediatric Academic Society annual meeting as the recipient of the
Society for Pediatric Research 2017 Young Investigator Award.
2/20/17: PUBLICATION
Our paper “Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci” is published in Nature Genetics. Amazing work Matt! Design CRISPR libraries here.
12/6/16: PRESENTATION
Dan presents at the Presidential Symposium on Sickle Cell Disease: New Biology, New Therapeutics at the American Society of Hematology annual meeting.
7/12/16: PUBLICATION
Our paper “Analyzing CRISPR genome-editing experiments with CRISPResso” is published in Nature Biotechnology. Thanks to Luca and GC for the fabulous collaboration. Analyze data with CRISPResso here.
6/1/16: MEMBERSHIP
Dan is appointed as faculty member in Leder Human Biology and Translational Medicine Program, Biological and Biomedical Sciences, Harvard Medical School.
5/7/16: PRESENTATION
Dan presented at the Genome Engineering 4.0 Workshop at the Broad Institute, Cambridge, MA.
5/4/16: PRESENTATION
Dan presents at the 19th Annual Gene and Cell Therapy Conference in Washington DC.
3/1/16: PRESENTATION
Dan delivers keynote presentation at Medical Scientist Training Program 2016 Winter Retreat, Case Western Reserve University School of Medicine.
9/25/15: PRESENTATION
Dan presents at the Cold Spring Harbor Laboratory meeting Genome Engineering: The CRISPR/Cas Revolution.
9/20/15: MEMBER
Dan is appointed Associate Member of the Broad Institute.
9/16/15: PUBLICATION
Our study of functional fine-mapping the BCL11A erythroid enhancer by Cas9-mediated in situ saturating mutagenesis is published in Nature.
9/1/15: WELCOME
Welcome to new research assistants Gina Butler and Connor McGuckin!
8/6/15: GRANT
Thanks to the Cooley’s Anemia Foundation for their support!
8/1/15: AWARD
Congratulations to Emily for receiving a 2015 American Society of Hematology (ASH) HONORS award!
7/31/15: PRESENTATION
Patrick presented at the PRADA’s You CAN Day Poster Session “Dissection of the BCL11A Enhancer by Cas9-medaited in situ saturation mutagenesis.”
7/13/15: WELCOME
Welcome to postdoctoral fellow Megan Hoban! Megan recently received her PhD from UCLA where she was mentored by Don Kohn.
7/6/15: WELCOME
Welcome to medical student Emily Stern from Tufts University School of Medicine. Emily, an ASH HONORS awardee, will be conducting full-time research for one year.
7/6/15: VISITING STUDENT
Welcome to visiting graduate student Samuel Lessard from Universite de Montreal! Sam is mentored by our collaborator Guillaume Lettre at the Montreal Heart Institute.
7/05/15: AWARD
Dan was the recipient of a 2015 Career Award for Medical Scientists from the Burroughs Wellcome Fund. See announcement: http://www.bwfund.org/newsroom/announcements/bwf-commits-225-million-advancing-biomedical-research-0
6/30/15: SUMMER STUDENT
Welcome to our summer student Baransel Kamaz, a medical student from Hacettepe University Faculty of Medicine, Turkey!
6/29/15: PRESENTATION
Dan presented at the Red Cells Gordon Research Conference “Functional BCL11A Enhancer Dissection by In Situ Cas9 Saturation Editing.”
6/18/15: ANALYSIS SOFTWARE
Our genome editing outcomes tool (developed by our friend Luca Pinello) is now available online, CRISPResso.rocks
6/8/15: SUMMER STUDENT
Welcome to our summer student Brenda Briones, an undergraduate from Instituto Tecnologico y de Estudios Superiores de Monterrey, Mexico! Brenda is an intern in the HSCI Internship Program.
6/3/15: SUMMER STUDENT
Welcome to our summer student Gerald Lilly, a medical student from Michigan State University! Gerald is participating in the Harvard Catalyst Visiting Research Internship Program.
5/28/15: PRESENTATION
Daniel Bauer was a featured guest at the Broad Institute NextGen Association Interest Meetup: “From genetics to function and mechanism.”
5/18/15: ANALYSIS SOFTWARE
CRISPResso beta version now available. This software, developed in collaboration with our colleagues Luca Pinello and GC Yuan, facilitates the quantification of genome editing outcomes from targeted deep sequencing.
5/14/15: PUBLICATION
Our JCI commentary “Embryonic stem cells as sources of donor-independent platelets” on the article “Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells” by Mitch Weiss and colleagues was published.
5/15/15: FELLOWSHIP AWARD
Congratulations to Matt Canver, MD/PHD candidate for receiving the National Institute of Health (NIH) F30 Predoctoral MD/PhD Research Fellowship Award for the project “Identification of Novel Regulators of Fetal Hemoglobin Expression.”
5/13/15: PRESENTATION AWARD
Congratulations to Falak Sher for winning the 2015 Folkman Research Day presentation award.
5/13/15: PRESENTATION
Post-doctoral fellow Falak Sher presented “in situ functional dissection of a disease-associated super-enhancer reveals a hierarchy of elements, evolutionary dynamism, and novel therapeutic targets” on May 13th, 2015 Folkman Research day.
5/13/15: PRESENTATION
Daniel Bauer presented “Therapeutic Genome Editing for the Hemoglobin Disorders” at the 18th Annual ASGCT Meeting on May 13th, 2015.
5/9/15: PRESENTATION
Daniel Bauer presented “Engineering the noncoding genome at high resolution” on May 9, 2015 at the Genome Engineering 3.0 workshop at the Broad Institute, Cambridge MA.